To reduce the risk of tearing the colon during this treatment, doctors often inject a saline solution into the space below the lesion, developing a “cushion” that elevates the polyp so that it is easier to remove safely. However, this cushioning doesn’t last long. MIT analysts have finally devised an alternative-a solution that can be injected as a water but becomes a good gel once it gets to the tissue, creating a far more stable and longer-lasting cushion.
Giovanni Traverso, an helper professor in MIT’s Department of Mechanical Engineering and a gastroenterologist at Brigham and Women’s Hospital. Traverso is the mature author of the scholarly research, in the July 30 issue of Advanced Science which shows up. The lead writers of the scholarly research are previous MIT postdocs Yan Pang and Jinyao Liu. Other authors include MIT undergraduate Zaina Moussa, technical associate Joy Collins, former technician Shane McDonnell, Division of Comparative Medicine veterinarian Alison Hayward, Brigham and Women’s Hospital gastroenterologist Kunal Jajoo, and David H. Koch Institute Professor Robert Langer. Even though many colon polyps are safe, some can eventually become cancerous if not removed.
Gastroenterologists often perform this procedure during a routine colonoscopy, using a lasso-like tool to snare the cells before slicing it off. Complex lesions can take 10 to 20 minutes to remove, or even longer, but the saline pillow only continues for a few minutes. Research workers have attempted to make the pads longer-lived with the addition of thickening realtors such as cellulose and gelatin, but those are very difficult to inject through the slim needle that can be used for the procedure. To overcome that, the MIT team decided to develop a shear-thinning gel. These materials are semisolid gels under normal conditions, however when force is applied to them, their viscosity lowers plus they easily flow more.
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This means that the materials can be easily injected through a slim needle, then reverse into a good gel once it exits into the colon tissues. Shear-thinning gels can be made from many types of materials. For this function, the researchers decided on a combination of two biocompatible materials that can develop gels-Laponite, a powdery clay used in makeup products and other products, and alginate, a polysaccharide produced from algae. Using these materials, the analysts created a shear-thinning gel that may be injected and form a well balanced cushion to get more than one hour, in pigs.
This would give gastroenterologists much more time to eliminate any polyps. By varying the structure of the gel components, the research workers can control features such as the viscosity, which affects how long the cushion remains stable. If made to last longer, this kind or kind of injectable gel could be useful for applications such as narrowing the GI tract, which could be used to prevent acid reflux or to help with weight loss by making people feel full. It might possibly be used to deliver drugs to the digestive tract also, Traverso says.
In general, it is strongly recommended that pregnancy be avoided over maximal weight reduction, the first 18-24 weeks after a gastric bypass typically. When pregnancy occurs, there’s a risk of malnutrition and anemia if ntritional supplements are not taken as advised. With that precaution in mind, studies of pregnancy after gastric bypass (6) and Lap Band (7) showed normal and healthy outcomes. A study from Australia (6) reported that pregnancy outcomes after Laparoscpic Adjustable Gastric Band Placement (Lap Band) are consistent with general community results rather than final results from significantly obese women. A indicated phrase of warning.
There have been reports of uncommon incidences of internal herniation causing dangerous bowel blockage late in pregnancy after laparoscopic gastric bypass. Waller DK, Shaw GM, Rasmussen SA, Hobbs CA, Canfield MA, Siega-Riz AM, Gallaway MS, Correa A; National Birth Defects Prevention Study. Prepregnancy obesity as a risk factor for structural delivery flaws. Arch Pediatr Adolesc Med. Ravelli GP, Stein ZA, Susser MW.